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Key Businesses
| Company | Industry | Location | Local Employees (est.) |
| IBM | Software | RTP | ~11,000 |
| GlaxoSmithKline | Pharmaceuticals | RTP (Regional HQ) | ~6,000 |
| SAS Institute | Software | Cary (HQ) | 4,228 |
| Progress Energy Utilities | Energy | Raleigh (HQ) | |
| Blue Cross Blue Shield North Carolina | Health Insurance | Chapel Hill/Durham (HQ) | 3,200 |
| Cisco Systems | Network Equipment | RTP | 2,950 |
| Nortel Networks | Telecom | RTP | 2,600 |
| Wachovia | Banking | Raleigh+ | 2,300 |
| Royal Bank of Canada | Banking | Raleigh (Regional HQ) | |
| First Citizen Bancshares | Banking | Raleigh (HQ) | |
| Verizon | Network Operations | Cary | 1,800+ |
| Talecris Biotherapeutics | Blood based medicine | RTP/Clayton | >1,400 |
| Cree Research | Technology | Durham (HQ) | 1,320 |
| Lenovo | Computers | Morrisville (US HQ) | 1,400 |
| Fidelity Investments | Finance | Various | 980 (plans to expand) |
| Quintiles Transnational | Pharmaceuticals | Durham (HQ) | 1100 (inc. Martin Cty.) (adding 900) |
| Caterpillar | Heavy Equipment | Cary/Clayton | 1,050 |
| AW North Carolina | Auto Transmissions | Durham | 1,000 |
| Stock Building Supply (Wolseley) | Materials | Raleigh (US HQ) | 950 |
| Network Appliances | Data Management | RTP | 800 (adding 200) |
| Coldwell Banker Howard Perry and Walston | Real Estate | Around Triangle | 800 |
| Biomerieux | Medical Testing Supplies | Durham | 800 |
| McClatchy/News and Observer | Media | Raleigh | 765+ | Misys | Software/Biotech | Raleigh (US HQ) | 730 |
| Sony Ericsson | Mobile Electronics | RTP (US HQ) | 750 (adding 100) |
| Diosynth (Schering-Plough) | Pharmaceutical Manufacturing | Cary/Morrisville/RTP | 750 |
| Fonville Morisey Realty (Long & Foster) | Real Estate | Raleigh | 710 |
| Siemens Medical Solutions | Medical Equipment | Cary | 678 |
| Tekelec | Telecom | Morrisville (HQ) | 650 |
| Wake Med | Hospital | Raleigh (HQ) | |
| SpectraSite Inc. (merged with American Tower) | Telecommunications | Cary (HQ) | |
| Flextronics (formerly Solectron) | Electronics | Morrisville | 650 |
| Biogen | Pharmaceuticals | RTP | 640 |
| Kellogg | Foods | Cary | 620 (adding 180) |
| Winston Hotels (Inland American) | Hotel | Raleigh (HQ) | |
| Charles and Colvard | Manufactured Jewels | Morrisville | |
| Waste Industries USA | Removal Services | Raleigh (HQ) | |
| Genworth Financial | Insurance | Raleigh | ~500 |
| Red Hat Inc. | Software | Raleigh (HQ) | 500 |
| Capital Bank Corp. | Raleigh | Banking (HQ) | |
| Alcatel (Lucent, Genesys) | Telecom | Raleigh/Cary/Morrisville | 350 Alcatel, 75 Lucent, 30 Genesys |
| Blackstone Group/Cardinal Health | Health Care Products | Raleigh/Morrisville/Durham | 450 |
| Noel Group, Nomacorc , Nomaco | Synthetic Corks/Foam Insulation and Toys | Wake Forest/Zebulon | 108 Nomacorc, 350 Nomaco |
| Credit Suisse | Financial | RTP | 350 (adding 400) |
| ABB Power Systems | Power Equipment | Raleigh/Cary | 358 (adding 60) |
| Eisai | Pharmaceutical | RTP | 339 |
| BD (Becton Dickinson) | Lab Equipment | Durham | 300 (adding 70) |
| American Kennel Club | Dog Registration | Raleigh | 300 |
| Parata Systems | Pharmacy Automation | Durham (HQ) | 300 |
| Sprint | Mobile Phones | Various | 300 |
| Harris Wholesale | Beverage Distribution | Raleigh | 285 |
| Allscripts (formerly A4) | Healthcare Software | Cary | 270 (adding 50) |
| General Electric | Jet Engines | Durham | 270 (adding 40) |
| INC Research | Pharmaceutical Testing | Raleigh (HQ) | 400 (expanding) |
| Investor's Title | Tite Insurance | Chapel Hill (HQ) | 259 |
| ValueOptions | Benefits Management | Morrisville | 220 (adding 55) |
| Salix | Pharmaceuticals | Raleigh | |
| Pozen Inc. | Biotech | Chapel Hill | |
| Trimeris Inc. | Biotech | Morrisville | |
| Martin Marietta Materials | Manufacturing | Raleigh (HQ) | 238 HQ |
| Icoria (bought by Clinical Data) | Biotech | RTP | |
| United General Title | Title Insurance | Raleigh (NC HQ) | |
| North State Bank | Banking | Raleigh (HQ) | |
| Investment Management Corp. (Golden Corral) | Restaurant | Raleigh (HQ) | |
| Burt's Bees (AEA) | Cosmetics | Durham | 350 (not all local) |
| Highwoods | Real Estate | Raleigh (HQ) | |
| Alliance One | Tobacco | Morrisville | |
| RTI International | Contract Research | RTP (HQ) | |
| Adherex Technologies | Pharmaceuticals | Durham | |
| Integrian | Surveillance Electronics | Morrisville (US HQ) | |
| Raleigh Lions Clinic for the Blind (Non Profit) | Manufacturing/Textiles | Raleigh (HQ) | 300 - 3/4 blind |
| Qualcomm | Chip Manufacturing | Cary | 200 (adding 150) |
| Art.com | Online Retail | Raleigh | 200+ |
| MeadWestvaco | Paper Goods | Raleigh | 70 (soon 200) |
| Merck | Pharmaceuticals | Durham | 175+ (coming) |
| McKinney (HAVS) | Advertising | Durham (US HQ) | 187 |
| ChannelAdvisor | Software (HQ) | Morrisville | 180 (adding 100) |
| Broadcom (LVL7) | Networking Software | Morrisville | 170 |
| Softpro | Real Estate Software | Raleigh | 170 (adding 130) |
| Ernst and Young | Accounting | Raleigh | 170 |
| Harris Stratex | Communications | Morrisville (HQ) | 170 |
| Embrex (Pfizer) | Biotech | Durham | 160 |
| Long Beverage | Beverage Distribution | Durham | 140 |
| Catalyst Manufacturing Services | Electronics | Morrisville | 140 |
| Empire Distributors | Beverage Distribution | Durham | 122 (growing to 145) |
| Teleflex | Medical Devices | RTP | 500 (regionally) |
| Healthways Inc. | Healthcare | Cary | 109+ |
| Scynexis | Pharmaceuticals | Durham (HQ) | 130 (adding 20) |
| Yard-Nique | Landscaping | Morrisville | 130 |
| PowerSecure | Power Management Systems | Wake Forest(HQ)/Raleigh | 125 |
| CIIT Centers for Health Research | Research | RTP (HQ) | 125 |
| SciQuest | Software | Cary (HQ) | 135 (not all local) |
| Poyner & Spruill LLC | Law | Raleigh (HQ) | 120 |
| Teradata (NCR) | Software | Raleigh | 120 |
| Etrials | Healthcare Services | Morrisville (HQ) | 120 |
| PharmaNet | Pharmaceutical Testing | Cary/Morrisville | 100 (adding 100) |
| Crescent Financial Corp. | Finance | Cary | >100 |
| Bank of America | Banking | Raleigh | >100 |
| The Redwoods Group | Insurance | Morrisville (HQ) | 103 |
| EMD Pharmaceuticals (Merck) | Pharmaceuticals | Durham | 100 |
| Closure Medical | Surgical Glue | Raleigh | 100 |
| Inspire | Pharmaceuticals | Durham (HQ) | 100 |
| Butterball | Turkeys | Garner (HQ) | 100 (by 2008) |
| Geomagic | Software | RTP (HQ) | 100 |
| Trinity Convergence | Telecom | Durham (HQ) | 100 |
| Technical Services Inc. | Construction | Durham (HQ) | 105 |
| Maupin Taylor (Williams Mullen) | Legal Services | Raleigh | 100 |
| Stewart Engineering | Civil Engineering | Raleigh/Morrisville (HQ) | 100 |
| Gilead | Pharmaceuticals | Durham | 100 |
| Motricity | Mobile Phone Content | Durham (HQ) | 100 |
| Implus Footcare | Foot Health | Morrisville | 100 (all local?) |
| Womble Carlyle | Legal Services | Raleigh/RTP | 90+ |
| Stiefel | Pharmaceuticals | RTP | 85 |
| French, West, Vaughn | Public Relations | Raleigh (HQ) | 82 |
| Raleigh Country Club | Golf | Raleigh | 80 |
| Square 1 Bank | Banking | Durham (HQ) | 80 |
| Treyburn Country Club | Golf | Durham | 80 |
| iContact | Marketing Software | Durham (HQ) | 80 |
| AlphaVax | Vaccines | RTP (HQ) | 77 |
| Arysta LifeScience | Agriculture Science | Cary | 72 |
| N.C. Mutual Life | Insurance | Durham (HQ) | 80 |
| Epic Games | Video Games | Cary (HQ) | 90 |
| Capstrat | Public Relations | Raleigh (HQ) | 80 |
| Icagen | Pharmaceutical | Durham | 60 |
| Consonus (Strategic Technologies) | IT Systems | Cary (HQ) | 70 |
| Olgivy Durham | Advertising | Durham | 70 (growing) |
| Bandwidth.com | Internet Telecom | Cary (HQ) | 69 |
| Compuware | Software | Durham | 69 |
| Hosted Solutions (ABRY) | Computer Hosting | Raleigh (HQ) | 50 |
| Triumph | Boats | Durham | 75 |
| SchoolDude.com | Educational Software | Cary (HQ) | 65 |
| Best Lab Deals | Scientific Supply | Garner | 65 |
| Lulu | Publishing | Raleigh | 65 |
| Buck Engineering (Baker) | Environmental Engineering | Cary | 63 |
| Ultimus | Automation Software | Cary | 60 |
| Bolton Service | Residential Repair | Raleigh | 60 |
| Accipiter Solutions (Atlas/aQuantive) | Internet Advertising | Raleigh | 57 |
| Headway Corporate Resources | Staffing | Raleigh | 177 (some in Edgecombe) |
| Curtis Media Group | Broadcasting | Raleigh (HQ) | |
| Copernicus Group | Pharmaceutical Testing | RTP (HQ) | 60 |
| MarketSmart Advertising | Advertising | Morrisville (HQ) | 56 |
| Trip Logics (World Travel) | Travel | Cary/Raleigh | 54+ |
| Cherokee Investment Partners | Real Estate | Raleigh (HQ) | 50 |
| Nitronex | Semiconductors | Raleigh (HQ) (soon Durham) | 55 |
| Smart Online | Business Software | Durham (HQ) | 50 |
| CB Richard Ellis ( Trammell Crow ) | Real Estate | Raleigh | 46 |
| Plant Delights | Nursery | Raleigh | 45 |
| TPS | Technical Writing | Raleigh (HQ) | 45 |
| MCNC | Networking/Research | RTP (HQ) | 45 |
| MercuryMD/Thomson | Biotech/Software | Durham | |
| Bright View Technologies | Optical Film | Morrisville (HQ) | 40 (growing) |
| rPath | Software | Raleigh (HQ) | 40 |
| Howard, Merrell and Partners | Advertising | Raleigh (HQ) | 40 |
| Relativity Technologies | Software | Raleigh (HQ) | 40 |
| Digital Lifestyle (Royal Philips) | IPod Accessories | Durham | 40 |
| Oasys Mobile (formerly Summus) | Phone Content | Raleigh (HQ) | 38 |
| First Research (Dun & Bradstreet) | Business Data | Raleigh | 38 |
| LiveWire Logic (acquired by Astute) | Software | Morrisville | |
| Cardinal State Bank (Yadkin Valley Financial) | Banking | Durham | |
| Gentris | Genetics | Morrisville (HQ) | 38 |
| InnerPulse | Medical Devices | RTP | 40 (adding 10) |
| Cenduit (Quintiles) | Pharmaceutical Testing | Durham (HQ) | 35 |
| Intervolve | Software | Raleigh (HQ) | 35 |
| Gateway Financial Holdings | Banking | Raleigh | 35 |
| Brock Cabinets | Cabinets/Countertops | Garner | 35 |
| United Therapeutics | Pharmaceuticals | RTP | 28 (adding 160) |
| Gibbs & Soell | Public Relations | Raleigh | 30 |
| Centice Corp. | High Tech/Optics | Morrisville (HQ) | 30 |
| CapTrust Financial Advisors | Investment | Raleigh (HQ) | 30 |
| American Research Institute | Simulation Software | Morrisville (HQ) | |
| Virtual Heroes | Video Games | RTP (HQ) | 30 |
| Capital Investment | Financial Services | Raleigh | 30 |
| Cortina Systems | Optical Networking | Morrisville | 30 |
| Serenex | Pharmaceuticals | Durham (HQ) | 30 |
| XS Inc. | Agricultural Software | Morrisville (HQ) | 30 |
| Red Storm Entertainment | Video Games | Morrisville | |
| Destineer | Video Games | Raleigh | |
| Elster Electricity | Metering Devices | Raleigh (HQ) | |
| Voyager Pharmaceuticals | Pharmaceuticals | Raleigh |
Government Employers
| Agency | Sector | Location | Local Employees (est.) |
| Wake County | Urban Administration | Raleigh, various | |
| City of Raleigh | Urban Administration | Raleigh | |
| Environmental Protection Agency (EPA) | Federal Research | RTP | |
| National Institute of Environmental Health Sciences (NIEHS) | Federal Research | RTP | 664 |
| NC Department of Environment and Natural Resources (DENR) | State Research | Raleigh | 630 |
| North Carolina Biotechnology Center | Biotechnology Promotion | RTP | 72 |
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